Ice antidotes

||Ecstasy poisoning #

@Ecstasy is a semi-synthetic, hallucinogenic substance =(MDMA, 3,4-methylenedioxymethamphetamine). @Its effects range from= nausea, muscle pain, blurred vision, amnesia, fever, confusion, and ataxia to tachyarrhythmias, hyperthermia, hyper/hypotension, water intoxication, DIC, K+↑, acute renal failure, hepatocellular and muscle necrosis, cardiovascular collapse, and ARDS. @There is no antidote and treatment is supportive. Management depends on clinical and lab findings, but may include:=

 Administration of activated charcoal and monitoring of BP, ECG, and temperature for at least 12h (rapid cooling may be needed).  Monitor urine output and U&E (renal failure p293), LFT, CK, FBC, and coagulation (DIC p336). Metabolic acidosis may benefit from treatment with bicarbonate.  Anxiety: diazepam 0.1-0.3mg/kg PO. Max IV does over 2min.  Narrow complex tachycardias in adults: consider metoprolol 5-10mg IV.  Hypertension can be treated with nifedipine 5-10mg PO or phentolamine 2-5mg IV. Treat hypotension conventionally (p778).